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Category: Isotope Labelled Compounds, Miscellaneous Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Light Gray Solid /// Application Notes: Isotope labelled Diglycolic Acid (D446330), is a known metabolite of Diethylene Glycol (D444285), which acts as a nephrotoxic agent in human proximal renal tubule cells. Diglycolic Acid is also used in the synthesis of N-interlinked imipramines which show apoptotic activity against malignant cells as well as signs of combatting Burkitt's lymphoma. /// References: Landry, G. et al.: Toxicol. Sci., 124, 35 (2011)| Besenhofer, L. et al.: Toxicol. Sci., 123, 374 (2011)| Bright, S. et al.: Bioorg. Med. Chem. Lett., 23, 1220 (2013)|