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Category: Aromatics, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: Off-White Solid /// Application Notes: Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP). /// References: Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010)| Tawil, R. et al.: Ann. Neurol., 47, 46 (2000)| Casey, J. et al.: J. Med. Chem., 47, 2337 (2004)|