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Category: Amines, Aromatics, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan carboxaldehyde is a derivative of Losartan carboxaldehyde (L470505). Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan carboxaldehyde is also used as reagent to synthesize Losartan Potassium (L470500), a an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients. /// References: Madasu, S., et al.: Org. Process Res. Dev., 16, 2025 (2012)| Pitt, B., et al.: The Lancet, 355, 1582 (2000)| Wachtell, K., et al.: J. Am. Coll. Cardiol., 45, 712 (2005)