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Beschreibung

Category: Amines, Aromatics, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Application Notes: Deshydroxy Sotalol Hydrochloride is an impurity in the synthesis of Sotalol (S677300), a potent alpha-adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period. /// References: Uloth, et al.: J. Med. Chem., 9, 88 (1966), Groh, W.J., et al.: Chirality, 5, 8 (1993), Pasnani, J.S., et al.: J. Pharmacol. Exp. Ther., 271, 184 (1994)