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Beschreibung

Category: Miscellaneous Reagents /// Appearance: White Solid /// Application Notes: trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (alpha-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain. /// References: Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012)| Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)