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Application Notes: (Z)-2-[(2-Chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester-d4 is the isotope labelled analog of (Z)-2-[(2-Chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester (C378115), an impurity in the synthesis of Amlodipine Besilate (A633500) which is a dihydropyridine calcium channel blocker that is also used as an antianginal and antihypertensive. /// References: Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986)| Burges, R.A., et al.: J. Cardiovasc Pharmacol., 9, 110 (1987)| Packer, M., et al.: N. Engl. J. Med., 335, 1107 (1996)