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Category: Miscellaneous Reagents /// Appearance: Clear Colorless to Pale Yellow Oil /// Application Notes: 1-Chloro-3-methyl-2-butene is a reactive allylic chloride that is used as an alkylating agent in synthetic chemistry. 1-Chloro-3-methyl-2-butene is also used as a reagent to synthesize Hyperforin, an antibiotic originating from St. John's wort that has the ability to inhibit growth of tumour cells. /// References: Hatch, L. & Gerhardt, L.: J. Am. Chem. Soc., 71, 1679 (1949)| Lee, M., et al.: Org. Lett., 6, 1241 (2004)| Reitsema, R. & Hunter, J.: J. Am. Chem. Soc., 71, 1680 (1949)| Schempp, C., et al.: Oncogene, 21, 1242 (2002)| Sparling, B., et al.: J. Am. Chem. Soc., 135, 644 (2013)