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Category: Amines, Aromatics, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Yellow Solid /// Application Notes: 4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate, a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib (G304000). /// References: Mayes, B.A., et al.: Org. Process Res. Dev., 14, 1248 (2010)| Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004)| Engelman, J.A., et al.: Science, 316, 1039 (2007)| Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)