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Category: Aromatics, MTS and Sulfhydryl Active Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: 2-Chloro-2',6'-dimethyl-d6-acetanilide is the labeled analogue of 2-Chloro-2',6'-dimethylacetanilide (C365375), an intermediate of Lidocaine (L397800), a local anesthetic, antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. /// References: Moen, A., et al.: Biocatal. Biotransform., 23, 45 (2005)| Yogeeswari, P., et al.: Bioorg. Med. Chem. Lett., 17, 3712 (2007)| Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971)| Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973)| Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985)| Davies, P.S., et al.: Drugs, 64, 937 (2004)