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Category: Apoptosis, Pharmaceuticals, Intermediates and Fine Chemicals, Protein Kinase Inhibitors and Activators, /// Appearance: White to Tan Solid /// Application Notes: CDDO Methyl Ester is a synthetic triterpenoid that inhibits I?Balpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor ?B-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer. /// References: Shishodia, S. et al.: Clin. Cancer Res., 12, 1828 (2006)| Konopleva, M. et al.: Leukemia, 19, 1350 (2005)| Deeb, D. et al.: Cancers, 2, 1779 (2010)| Gao, X. et al.: J. Exp. Therap. Oncol., 9, 119 (2011)|