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Application Notes: 1-(4-Carboxybutyl)-3,7-dimethylxanthine is a main metabolite of Pentoxifylline (P276500), a compound that increases erythrocyte flexibility, reduces blood viscosity, and inhibits platelet aggregation and can thus be used in the treatment of peripheral vascular disease. /// References: Magnusson, M., et al.: Eur. J. Pharmacol., 581, 290 (2008)| Fantin, M., et al.: Eur. J. Pharmacol., 535, 301 (2006)| Nicklasson, M., et al.: Chirality, 14, 643 (2002)| Honess, D.J., et al.: Radiother. Oncol., 28, 208 (1993)