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Category: Aliphatics, Isotope Labelled Compounds, Neurochemicals /// Appearance: Yellow Oil to Yellow Semi-Solid /// Application Notes: Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-beta peptide toxicity associated with Alzheimer's disease. Diacetyl accelerates amyloid-beta aggregation-a hallmark of Alzheimer's disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA. /// References: Wang, J., et al.: Exp. Neurol., 158, 328 (1999)| Brown, M., et al.: Cell, 100, 391 (2000)| Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006)| Brody, D., et al.: Science, 321, 1221 (2008)| More, S., et al.: J. Med. Chem., 52, 4650 (2009)|