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Category: Amines, Aromatics, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: 3'-Bromopropiophenone is used as a reagent to synthesize kinase spindle protein inhibitors (such as Ispinesib [I918500]) that also act as antitumour agents in vivo. 3'-Bromopropiophenone is also an inhibitor of cruzain, an essential protease that originates in the parasite Trypanosoma cruzi. /// References: Gillmor, S., et al.: Prot. Sci., 6, 1603 (1997)| Leite, A., et al.: ChemMedChem, 2, 1339 (2007)| Wang, F., et al.: J. Med. Chem., 55, 1511 (2012)