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Category: Aromatics, Heterocycles, Isotope Labeled Compounds, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: 8-Bromo-3,7-dihydro-3-methyl-7-(phenylmethyl)-1H-purine-2,6-dione-d5, is the labeled analogue of (B683480), which is a substituted derivative of of Xanthine (X499950), found in animal organs, yeast, potatoes, coffee beans, tea. It can also be used for the synthesis of Linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes. /// References: Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)| Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011)| Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011)| Mtthias E., et. al: J. Med. Chem., 50, 6450 (2007)|