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Category: Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Light Yellow Solid /// Application Notes: Azimilide-d8 Dihydrochloride is the isotope labelled analog of Azimilide dihydrochloride. Azimilide Dihydrochloride is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction. /// References: Tran, H.T., et al.: Heart. Dis., 1, 114 (1999)| Conway, E., et al.: Am. J. Cardiol., 102, 12 (2008)| Carlson, M., et al.: Exp. Rev. Cardio. Therap., 3, 387 (2005)| Dorian, P., et al.: J. Cardio. Pharm. Therap., 7, 211 (2002)|