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Category: Amines, Aromatics, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: 2-(Aminomethyl)pyrazine is a useful synthetic intermediate. It is used to synthesize pyrazolo[4,3-c]pyridinediones as orally bioavailable NADPH oxidase isoform 4 inhibitors for the treatment of idiopathic pulmonary fibrosis. It is also used to prepare pyrazolyl-indoles with the abilities to induce T-cell kinase inhibition. /// References: Laleu, B., et al.: J. Med. Chem., 53, 7715 (2010)| Velankar, A., et al.: Bioorg. Med. Chem., 18, 4547 (2010)