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Category: Amines, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Dark Yellow to Brown Solid /// Application Notes: 3-Amino-5,6-dichloro-2-pyrazinecarboxylic Acid Methyl Ester, is used for the preparation of 2-Amidino analogs of glycine-Amiloride (A578700) conjugates, acting as inhibitors of the protease urokinase plasminogen activator (uPA), a promising anticancer targets. /// References: Massey, A. P., et al.: Bioorg. Med. Chem. Lett., 22, 2635 (2012)| Matthews, H., et al.: Bioorg. Med. Chem. Lett., 21, 6760 (2011)|