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Category: Heterocycles, Nucleotides, Bases and Related Reagent, Protein Kinase Inhibitors and Activators /// Appearance: Off-White to Pale Beige Solid /// Application Notes: 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival. /// References: Eblen, S., et al.: J. Biol. Chem., 278, 14926 (2003), Lindsley, C., et al.: Bioorg. Med. Chem. Lett., 15, 761 (2005), Manning, B., et al.: Cell, 129, 1261 (2007), Heerding, D., et al.: J. Med. Chem., 51, 5663 (2008)