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Beschreibung

"Vascular injury is important to address during the preclinical safety study of drugs. A lack of well-defined mechanisms of drug-induced vascular injury (DIVI) in animals, and the absence of specific, qualified biomarkers have become significant barriers in the development of new therapeutic treatments. In the past, hemodynamics, such as heart rate and mean arterial blood pressure, were used to measure DIVI risks but these only targeted single biomarkers. Today, some of the known vascular injury mechanisms are related to vascular wall shear and/or circumferential ""hoop"" stress, drug/chemical toxicity, and immunological mediation. With these known biomechanics, primary targets (smooth muscle, endothelial and immune-mediated cells) yield a number of promising candidate biomarkers for DIVI study. We provide valuable research assays to investigate multiple biomarkers of vascular injury in rat serum and plasma samples using the Luminex(R) xMAP(R) instrument platform. The MILLIPLEX(R) Rat Vascular Injury Bead Panel 2 contains all the components necessary to measure the following four biomarkers in any combination using Luminex(R) xMAP(R) technology: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF). The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate. Panel Type: Toxicity"