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Beschreibung

The neurotransmitter serotonin/5-hydroxytryptamine (5-HT) regulates a wide variety of neurological functions. A family of 13 receptors (12 GPCRs and one ion channel) mediate the effects of serotonin. The serotonin receptor 5-HT6 is a Gs coupled receptor expressed solely in the CNS, primarily in the limbic and cortical regions. 5-HT6 appears to play a role in memory and learning, obesity, psychosis, anxiety and epilepsy (Woolley et al., 2004, Fisas et al., 2006). In particular, a 5-HT6-selective agonist caused significant weight loss in a rat model of diet-induced obesity. Millipore&prime,s 5-HT6 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression, thus, they are ideal HTS tools for screening of agonists and antagonists of 5-HT6. The membrane preparations exhibit a Kd of 0.44 nM for [125I]-SB258585. With 0.25nM [125I]-SB258585, 5 &mu,g/well 5-HT6 Membrane Prep typically yields greater than 6-fold signal-to-background ratio., Full-length human HTR6 cDNA encoding the 5-HT6 Serotonin Receptor