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Beschreibung

A highly sensitive and specific assay for measuring Calpain 1 and 2 activity in biological samples like cell lysate or tissue extracts and for screening enzyme inhibitors. Calpains (calcium ion-dependent papain-like cysteine proteases) are widely distributed in all mammalian cells. They mediate calcium-induced activation of the Erk1/Erk2 MAPK pathway and are believed to participate in intracellular signal processing via limited proteolysis of their targets.. Sensitive: detects calpain activity at 63-1000 ng/ml. Specific: Substrate and inhibitor optimized for specific detection of calpain activity. Versatile: Homogeneous 96-well format can be used with biological samples or for inhibitor screens. Convenient: Contains all reagents to assay samples in 30 min