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Beschreibung

Transcription factor HES-1 (HES-1) also known as Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.