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Beschreibung

Sorting nexin-18 (UniProt Q96RF0, also known as SH3 and PX domain-containing protein 3B, Sorting nexin-associated Golgi protein 1) is encoded by the SNX18 (also known as SNAG1, SH3PX2, SH3PXD3B) gene (Gene ID 112574) in human. SNX18, SNX33, and SNX9 constitute a subfamily of sorting nexin (SNX) proteins characterized by a Bin-Amphiphysin-Rvs (BAR) domain that allows dimerization. It also contributes to modulation and shaping of membrane curvature. It also has a Src-homology 3 (SH3) domain that allows interaction with a wide range of proline-rich PXXP motif containing proteins. In addition to mediating endocytosis and intracellular vesicle trafficking, SNX18, SNX33, and SNX9 are also essential for successful completion of the ingression and abscission stages of cytokinesis and for the delivery of a subset of vesicles to the intracellular bridge that connects the two nascent daughter cells during mitosis. GSK‐,3 is reported to prevent FIP5-SNX18 interaction during metaphase and anaphase in Madin‐,Darby canine kidney (MDCK) cells by catalyzing FIP5 Thr276 phosphorylation to ensure the fidelity and timing of FIP5‐,endosome targeting to the AMIS during apical lumen formation.