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Beschreibung

A cell-permeable, reversible and selective peptidomimetic inhibitor of gamma-secretase (IC50 = 13 µ,M for Abeta). Displays only weak inhibitory activity against calpain II (IC50 = 100 µ,M in a purified enzyme assay).Please note that the molecular weight for this compound is batch-specific due to variable water content., A cell-permeable, reversible and selective peptidomimetic inhibitor of gamma-secretase with an IC50 of 13 µ,M for the inhibition of amyloid beta-protein (Abeta) production in beta-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC50 = 100 µ,M in a purified enzyme assay).