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Beschreibung

A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCalpha) that efficiently enhances non-amyloidogenic alpha-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity., A cell-permeable PKC activator (Ki = 11.9 nM for PKCalpha) that efficiently enhances non-amyloidogenic alpha-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.