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Beschreibung

A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCalpha, 8 nM for PKCbetaI, 14 nM for PKCbetaII, 13 nM for PKCgamma, and 39 nM for PKCepsilon). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow., A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCalpha, 8 nM for PKCbetaI, 14 nM for PKCbetaII, 13 nM for PKCgamma, and 39 nM for PKCepsilon). Shows slight selectivity for the conventional PKC isozymes PKCalpha, PKCbeta, and PKCgamma over the Ca2+-independent PKC isozyme PKCepsilon. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.