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Beschreibung

A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 µ,M. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCalpha, and SAPK2a/p38alpha. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000, IC50 = ~5 µ,M), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 µ,M in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µ,M., A cell-permeable, selective, reversible, and ATP-competitive inhibitor of Rho kinase activity (IC50 = 25 µ,M). Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCalpha, and SAPK2a/p38alpha. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000, IC50 ~5 µ,M), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 ~12 µ,M in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µ,M.