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Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Artikelnr.

SAF-539211-50MG

CAS-Nummer

[17372-87-1]

Einheit

1 x 50 mg

Molekularformel

C20H6Br4Na2O5

Molekulargewicht

691,85

Transportdaten

No Dangerous Good /not restricted

Preis auf Anfrage

Beschreibung

A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µ,M, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).

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