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Beschreibung

A cell-permeable quinazolinamine based compound that acts as a highly selective, non-ATP-competitive, and reversible inhibitor of phosphatidylinositol-5-phosphate-4-kinase &gamma, (PI5P4K&gamma,, apparent IC50 ~ 3.3 microM), but does not inhibit the activity of PI5P4K&alpha, and PI5P4K&beta, even at higher concentration (~100 microM). Suggested to bind at the PI5P binding region, including the activation loop. Also shown to be effective against E378H, I159V, and D161V mutant forms of PI5P4K&gamma, (71% inhibition at 10 microM). However, N165I mutant enzyme is resistant to its action even at higher concentration (~50 microM). Blocks the translocation of Na+/K+-ATPase to the plasma membrane in confluent mouse principal kidney cortical collecting duct (mpkCCD) cells in culture and prevents dome formation., A cell-permeable quinazolinamine based compound that acts as a highly selective, non-ATP-competitive, and reversible inhibitor of phosphatidylinositol-5-phosphate-4-kinase &gamma, (PI5P4K&gamma,, apparent IC50 ~ 3.3 microM), but does not inhibit the activity of PI5P4K&alpha, and PI5P4K&beta, even at higher concentration (~100 microM). Suggested to bind at the PI5P binding region, including the activation loop. Also shown to be effective against E378H, I159V, and D161V mutant forms of PI5P4K&gamma, (71% inhibition at 10 microM). However, N165I mutant enzyme is resistant to its action even at higher concentration (~50 microM). Blocks the translocation of Na+/K+-ATPase to the plasma membrane in confluent mouse principal kidney cortical collecting duct (mpkCCD) cells in culture and prevents dome formation.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.