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Beschreibung

A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1alpha accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120 nM vs 2.44 µ,M, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. >=2 µ,M) under hypoxia conditions.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water., A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1alpha accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating von Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120 nM vs 2.44 µ,M, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress the mRNA levels of HIF-1 target genes in HCT116 cultures (VEGF, EPO, and MMP-9, effective conc. >=2 µ,M) and effectively inhibit HUVEC tubule formation (effective conc. 2 to 5 µ,M) under hypoxia conditions.