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Beschreibung

A cell-permeable diterpenoid compound that possesses anti NF-kappaB activity and displays antiproliferative (ED50 = ~ 2.7 µ,g/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µ,g/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-alpha and LPS-induced NF-kappaB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-kappaB transcriptional activity (IC50 = ~ 5 µ,g/ml in MT-1 cells) by disrupting NF-kappaB DNA-binding activity without interfering with its nuclear translocation., A cell-permeable inhibitor of NF-kappaB activity that displays antiproliferative (ED50 ~ 2.7 µ,g/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µ,g/ml). Reported to affect DNA synthesis, induce apoptosis, and initiate cell cycle arrest. Shown to efficiently block both TNF-alpha and LPS-induced NF-kappaB activity in Jurkat and in RAW264.7 murine macrophages. Also inhibits p65 NF-kappaB transcriptional activity (IC50 ~5 µ,g/ml in MT-1 cells) by disrupting NF-kappaB DNA-binding activity without interfering with its nuclear translocation.