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Beschreibung

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase., An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.