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Beschreibung

A cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC50 = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µ,M). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µ,M). It has no effect on PKA (at concentrations up to 1 mM) or PKC (at concentrations up to 420 µ,M)., A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC50 = 100 µ,M) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µ,M). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µ,M).