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Beschreibung

A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil, Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µ,M using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKbeta, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.