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Beschreibung

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µ,M), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µ,M inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 <=40 µ,M) and induce chromatin condensation in HeLa cells., A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µ,M), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µ,M inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 <= 40 µ,M) and induce chromatin condensation in HeLa cells.