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Beschreibung

A highly potent, reversible, and substrate competitive membrane-permeable peptide that selectively inhibits protein kinase G Ialpha (PKG Ialpha) (Ki = 25 nM). Inhibitor peptide is fused to the Drosophila Antennapedia homeo domain peptide to allow membrane permeability. Shown to efficiently cross the membrane of arterial smooth muscle cells and inhibit nitric oxide-induced (NO-induced) vasodilation (EC50 = 47 µ,M). Inhibits protein kinase A (PKA) activity only at much higher concentrations (Ki = 493 µ,M). The carrier peptide is also available under Cat. no. 287895., A highly potent, reversible, and substrate competitive membrane-permeable Drosophila Antennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Ialpha (Ki = 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED50 = 47 µ,M). Inhibits protein kinase A at much higher concentrations (Ki = 493 µ,M). The carrier peptide is also available under Cat. no. 287895.