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Beschreibung

A potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs), (Ki = 400 pM for MMP-1, Ki = 500 pM for MMP-2, Ki = 27 nM for MMP-3, Ki = 100 pM for MMP-8, and Ki = 200 pM for MMP-9). Prevents the release of TNF-alpha in vivo and in vitro and abrogates endotoxin-induced lethality in mice. A 10 mM (1 mg/257 µ,l) solution of GM6001 (Cat. No. 364206) in DMSO is also available., A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1), Ki = 0.5 nM for gelatinase A (MMP-2), Ki = 27 nM for stromelysin (MMP-3), Ki = 0.1 nM for neutrophil collagenase (MMP-8), and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-alpha in vivo and in vitro and abrogates endotoxin-induced lethality in mice.