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Beschreibung

A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3beta (IC50 = 30 nM). Binds to GSK-3beta with high-affinity (Kd = 126 nM) and increases the level of beta-catenin, a downstream substrate of GSK-3beta in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19, 30-40% at 1 µ,M) and embryonic stem cells (D3, 50-60% at 400 nM)., A cell-permeable and potent inhibitor of GSK-3beta (IC50 = 30 nM). Binds to GSK-3beta with high-affinity (Kd = 126 nM), leading to an increase in the level of beta-catenin, a downstream substrate of GSK-3beta in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19, 30-40% at 1 µ,M) and embryonic stem cells (D3, 50-60% at 400 nM).