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Beschreibung

A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3beta (IC50 = 2 µ,M). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µ,M, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 µ,M). Shown to inhibit collagen- and thrombin-induced platelet aggregation., A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3beta (IC50 = 2 µ,M). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µ,M, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 >100 µ,M). Binds to the active site of GSK-3beta.