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Beschreibung

Factor B, Human, is a single-chain glycoprotein present in normal human serum that is cleaved during the activation of complement via the alternative pathway into two fragments of 30 and 63 kDa., Native factor B from human serum. Single-chain glycoprotein present in normal human serum at about 200 µ,g/ml. During activation of complement via the alternative pathway, Factor B is cleaved, and thus activated by Factor D into two fragments of M.W. of ~30 kDa (Ba) and ~63 kDa (Bb). The Bb fragment contains the serine protease enzymatic active site. The activated Bb fragment continues activation via the alternative pathway by cleaving, and thus activating, C3 and C5., Native factor B from human serum. Single-chain glycoprotein present in normal human serum at about 200 µ,g/ml. During activation of complement via the alternative pathway, Factor B is cleaved and thus activated by Factor D into two fragments of M.W. of 30 kDa (Ba) and 63 kDa (Bb). The Bb fragment contains the serine protease enzymatic active site. The activated Bb fragment continues activation via the alternative pathway by cleaving, and thus activating, C3 and C5.