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Beschreibung

A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µ,M). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 14.8 µ,M) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo., A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µ,M). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 µ,M). Also suppresses HER2/neu tyrosine kinase activity in HER2/neu overexpressing breast cancer cells.