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Beschreibung

beta-catenin is a multifunctional protein, it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of beta-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of beta-catenin have been implicated in a number of human cancers., N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.