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Beschreibung

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µ,M. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µ,M, respectively). Does not significantly inhibit cathepsin L., A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µ,M. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µ,M, respectively). Does not significantly inhibit cathepsin L.