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Beschreibung

A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µ,M) and reversibly blocks the gliding motility. It also weakens myosin's interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II., An aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µ,M). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µ,M). Reversibly blocks gliding motility of skeletal muscle myosin (IC50<2 µ,M). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.