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Beschreibung

A highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCalpha, betaI, betaII, gamma, delta, and epsilon isozymes. May inhibit protein kinase A at a much higher concentration (Ki = 2 µ,M). Also inhibits telomerase A treated NPC-076 cells. A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.