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Category: Chiral Reagents, Inhibitors, Mutagenesis Research Chemicals, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White to Off-White Solid /// Application Notes: Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Deoxynivalenol exhibits cytotoxic activity in vivo via the ribotoxic stress response. Deoxynivalenol induces p38-mediated gene expression and apoptosis in leukocytes, activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-?B into the nucleus.Environmental contaminants, Food contaminants /// References: Bae, et al.: Toxicol. Sci., 105, 59 (2008), Shi, et al.: Toxicol. Sci., 109, 247 (2009), Krishnaswamy, et al.: Free Radic. Biol. Med., 49 50 (2010)