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Category: Aromatics, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: 4,4'-DDE is a metabolite of DDT (D434195), a synthetic organochlorine insecticide that functions by opening sodium ion channels in the insects' neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-DDE has shown to have endocrine disrupting effects on gonadotropin hormones in pituitary gonadotrope cells. /// References: Saschenbrecker, P.W.: Can. J. Comp. Med., 37, 203 (1973)| Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010)| Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010)| Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989)| Zhou, J., et. al.: Environ. Toxicol. Phar., 37, 1194 (2014)