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Category: Amino Acids and Derivatives, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White to Off-White Solid /// Application Notes: Darinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells.  Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential. /// References: Tian, J., et al.: Clin. Cancer Res., 18, 3366 (2012)| Ning, S., et al.: Int. J. Radiat. Oncol. Biol. Phys., 65, 493 (2006)|