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Beschreibung

Category: Aromatics, Heterocycles, Metabolites and Impurities, Nucleotides, Bases and Related Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Pale Beige Solid /// Application Notes: The major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys.  NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (beta anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (alpha and beta anomers). /// References: Becker, B., et al.: Biochem. J., 314, 249 (1996), Bailey, M., et al.: Chem. Biol. Interact., 145, 117 (2004), Blech, S., et al.: Drug Metab. Dispos., 2008, 36, 386 (2008)